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anti 5 ht6r  (Bioss)


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    Bioss anti 5 ht6r
    Regulatory effect of EA pretreatment on hippocampal JNK signaling. (A-I) Western blotting was used to detect the protein levels of <t>5-HT6R,</t> c-Jun, p-c-Jun, JUK, and p-JUK in the hippocampus. The data are expressed as mean±SD (n=3). Compared with the model group, P <0.05; compared with the EV-GV20+ST36 group, P <0.05
    Anti 5 Ht6r, supplied by Bioss, used in various techniques. Bioz Stars score: 93/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/5ht6+receptor+sr-6+polyclonal+antibody/pmc10083831-82-25-30?v=Bioss
    Average 93 stars, based on 2 article reviews
    anti 5 ht6r - by Bioz Stars, 2026-07
    93/100 stars

    Images

    1) Product Images from "The gut-brain axis: Effect of electroacupuncture pretreatment on learning, memory, and JNK signaling in D-galactose-induced AD-like rats"

    Article Title: The gut-brain axis: Effect of electroacupuncture pretreatment on learning, memory, and JNK signaling in D-galactose-induced AD-like rats

    Journal: Iranian Journal of Basic Medical Sciences

    doi: 10.22038/IJBMS.2023.66954.14683

    Regulatory effect of EA pretreatment on hippocampal JNK signaling. (A-I) Western blotting was used to detect the protein levels of 5-HT6R, c-Jun, p-c-Jun, JUK, and p-JUK in the hippocampus. The data are expressed as mean±SD (n=3). Compared with the model group, P <0.05; compared with the EV-GV20+ST36 group, P <0.05
    Figure Legend Snippet: Regulatory effect of EA pretreatment on hippocampal JNK signaling. (A-I) Western blotting was used to detect the protein levels of 5-HT6R, c-Jun, p-c-Jun, JUK, and p-JUK in the hippocampus. The data are expressed as mean±SD (n=3). Compared with the model group, P <0.05; compared with the EV-GV20+ST36 group, P <0.05

    Techniques Used: Western Blot



    Similar Products

    anti 5 ht6r  (Bioss)
    93
    Bioss anti 5 ht6r
    Regulatory effect of EA pretreatment on hippocampal JNK signaling. (A-I) Western blotting was used to detect the protein levels of <t>5-HT6R,</t> c-Jun, p-c-Jun, JUK, and p-JUK in the hippocampus. The data are expressed as mean±SD (n=3). Compared with the model group, P <0.05; compared with the EV-GV20+ST36 group, P <0.05
    Anti 5 Ht6r, supplied by Bioss, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/5ht6+receptor+sr-6+polyclonal+antibody/pmc10083831-82-25-30?v=Bioss
    Average 93 stars, based on 1 article reviews
    anti 5 ht6r - by Bioz Stars, 2026-07
    93/100 stars
    		  Buy from Supplier
    antibody anti rabbit 5 ht 6 receptor  (Bioss)
    93
    Bioss antibody anti rabbit 5 ht 6 receptor
    Microinjection of the selective 5-HT 6 receptor agonists into the contralateral VLO reduced SNI-induced allodynia. (A) Scatter plots showing no difference of PWT between naïve and sham animals. (B,E) Time-course curves showing the inhibitory effect of different doses of EMD-386088 and WAY-208466 on allodynia induced by SNI. (C,F) Scatter plots showing the inhibitory effect of different doses of EMD-386088 and WAY-208466 on allodynia during the 60-min observation period. (D) The locomotor activity in an open-field test was not affected after microinjection of 10 μg EMD-386088 into the VLO. * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001 compared with the vehicle group; # p < 0.05, ## p < 0.01, and ### p < 0.001, compared with the 2.5 μg EMD group. n = 6–15 rats/group.
    Antibody Anti Rabbit 5 Ht 6 Receptor, supplied by Bioss, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/5ht6+receptor+sr-6+polyclonal+antibody/pmc07461796-95-9-14?v=Bioss
    Average 93 stars, based on 1 article reviews
    antibody anti rabbit 5 ht 6 receptor - by Bioz Stars, 2026-07
    93/100 stars
    		  Buy from Supplier

    Image Search Results


    Regulatory effect of EA pretreatment on hippocampal JNK signaling. (A-I) Western blotting was used to detect the protein levels of 5-HT6R, c-Jun, p-c-Jun, JUK, and p-JUK in the hippocampus. The data are expressed as mean±SD (n=3). Compared with the model group, P <0.05; compared with the EV-GV20+ST36 group, P <0.05

    Journal: Iranian Journal of Basic Medical Sciences

    Article Title: The gut-brain axis: Effect of electroacupuncture pretreatment on learning, memory, and JNK signaling in D-galactose-induced AD-like rats

    doi: 10.22038/IJBMS.2023.66954.14683

    Figure Lengend Snippet: Regulatory effect of EA pretreatment on hippocampal JNK signaling. (A-I) Western blotting was used to detect the protein levels of 5-HT6R, c-Jun, p-c-Jun, JUK, and p-JUK in the hippocampus. The data are expressed as mean±SD (n=3). Compared with the model group, P <0.05; compared with the EV-GV20+ST36 group, P <0.05

    Article Snippet: The membrane was blocked with 5% skim milk in Tris buffer containing 0.1% Tween-20 (TBS-T) at room temperature for 1 hr and then incubated using anti-5-HT6R (1:500, catalog no. bs-12058R, Bioss), anti-JNK (1:2000, catalog no. 9252, CST), anti-P-JNK (1:1000, catalog no. 4668, CST), anti-c-JUN (1:1000, catalog no. Ab32137, Abcam), and anti-P-c-JUn (1:1000, catalog no. 2361, CST) primary antibodies overnight at 4 °C.

    Techniques: Western Blot

    Microinjection of the selective 5-HT 6 receptor agonists into the contralateral VLO reduced SNI-induced allodynia. (A) Scatter plots showing no difference of PWT between naïve and sham animals. (B,E) Time-course curves showing the inhibitory effect of different doses of EMD-386088 and WAY-208466 on allodynia induced by SNI. (C,F) Scatter plots showing the inhibitory effect of different doses of EMD-386088 and WAY-208466 on allodynia during the 60-min observation period. (D) The locomotor activity in an open-field test was not affected after microinjection of 10 μg EMD-386088 into the VLO. * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001 compared with the vehicle group; # p < 0.05, ## p < 0.01, and ### p < 0.001, compared with the 2.5 μg EMD group. n = 6–15 rats/group.

    Journal: Frontiers in Neuroscience

    Article Title: The 5-HT 6 Receptors in the Ventrolateral Orbital Cortex Attenuate Allodynia in a Rodent Model of Neuropathic Pain

    doi: 10.3389/fnins.2020.00884

    Figure Lengend Snippet: Microinjection of the selective 5-HT 6 receptor agonists into the contralateral VLO reduced SNI-induced allodynia. (A) Scatter plots showing no difference of PWT between naïve and sham animals. (B,E) Time-course curves showing the inhibitory effect of different doses of EMD-386088 and WAY-208466 on allodynia induced by SNI. (C,F) Scatter plots showing the inhibitory effect of different doses of EMD-386088 and WAY-208466 on allodynia during the 60-min observation period. (D) The locomotor activity in an open-field test was not affected after microinjection of 10 μg EMD-386088 into the VLO. * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001 compared with the vehicle group; # p < 0.05, ## p < 0.01, and ### p < 0.001, compared with the 2.5 μg EMD group. n = 6–15 rats/group.

    Article Snippet: After washing in PBS, sections were incubated with primary antibody anti-rabbit 5-HT 6 receptor (Bioss, bs-12058R, 1:1,000, Beijing, China) and anti-goat neuronal glutamate transporter (EMD Millipore, AB1520, 1:8,000, Temecula, CA, United States) for 48 h at 4°C.

    Techniques: Activity Assay

    The expression of 5-HT 6 receptors protein level was specifically decreased in the contralateral VLO after SNI. (A) Representative Western blotting and (B) summary scatter plots showing the 5-HT 6 receptors of the VLO in control (sham) and SNI rats. ** p < 0.01 and ## p < 0.01 vs corresponding control and contralateral group, respectively. n = 4 rats/group. 5-HT6R, 5-HT 6 receptors.

    Journal: Frontiers in Neuroscience

    Article Title: The 5-HT 6 Receptors in the Ventrolateral Orbital Cortex Attenuate Allodynia in a Rodent Model of Neuropathic Pain

    doi: 10.3389/fnins.2020.00884

    Figure Lengend Snippet: The expression of 5-HT 6 receptors protein level was specifically decreased in the contralateral VLO after SNI. (A) Representative Western blotting and (B) summary scatter plots showing the 5-HT 6 receptors of the VLO in control (sham) and SNI rats. ** p < 0.01 and ## p < 0.01 vs corresponding control and contralateral group, respectively. n = 4 rats/group. 5-HT6R, 5-HT 6 receptors.

    Article Snippet: After washing in PBS, sections were incubated with primary antibody anti-rabbit 5-HT 6 receptor (Bioss, bs-12058R, 1:1,000, Beijing, China) and anti-goat neuronal glutamate transporter (EMD Millipore, AB1520, 1:8,000, Temecula, CA, United States) for 48 h at 4°C.

    Techniques: Expressing, Western Blot

    Effects of the selective 5-HT 6 receptor antagonist SB-258585 on EMD- and WAY-induced anti-allodynia. (A,C) Time course curves showing the antagonizing effect of SB-258585 on EMD- and WAY-induced inhibition of allodynia. (B,D) Scatter plots showing the antagonizing effect of SB-258585 on EMD- and WAY-induced inhibition of allodynia during the 60-min observation period. (E) Time-course curves showing no effect of different doses of SB-258585 on allodynia induced by SNI. (F) Scatter plots showing no effect of different doses of SB-258585 on allodynia during the 60-min observation period. ** p < 0.01, *** p < 0.001, and **** p < 0.0001 compared with the vehicle group; # p < 0.05, ## p < 0.01, ### p < 0.001, and #### p < 0.0001 compared with the 10 μg EMD and 8 μg WAY group. n = 6–12 rats/group.

    Journal: Frontiers in Neuroscience

    Article Title: The 5-HT 6 Receptors in the Ventrolateral Orbital Cortex Attenuate Allodynia in a Rodent Model of Neuropathic Pain

    doi: 10.3389/fnins.2020.00884

    Figure Lengend Snippet: Effects of the selective 5-HT 6 receptor antagonist SB-258585 on EMD- and WAY-induced anti-allodynia. (A,C) Time course curves showing the antagonizing effect of SB-258585 on EMD- and WAY-induced inhibition of allodynia. (B,D) Scatter plots showing the antagonizing effect of SB-258585 on EMD- and WAY-induced inhibition of allodynia during the 60-min observation period. (E) Time-course curves showing no effect of different doses of SB-258585 on allodynia induced by SNI. (F) Scatter plots showing no effect of different doses of SB-258585 on allodynia during the 60-min observation period. ** p < 0.01, *** p < 0.001, and **** p < 0.0001 compared with the vehicle group; # p < 0.05, ## p < 0.01, ### p < 0.001, and #### p < 0.0001 compared with the 10 μg EMD and 8 μg WAY group. n = 6–12 rats/group.

    Article Snippet: After washing in PBS, sections were incubated with primary antibody anti-rabbit 5-HT 6 receptor (Bioss, bs-12058R, 1:1,000, Beijing, China) and anti-goat neuronal glutamate transporter (EMD Millipore, AB1520, 1:8,000, Temecula, CA, United States) for 48 h at 4°C.

    Techniques: Inhibition

    The blocking effects of the non-selective glutamate receptor antagonist KA on EMD-induced anti-allodynia in the VLO. (A) The colocalization of 5-HT 6 receptors and EAAC1 in the VLO. Scale bar, 50 μm; n = 4 rats/group. (B) Time course curves showing the antagonizing effect of KA on EMD-induced inhibition of allodynia. (C) Scatter plots showing the antagonizing effect of KA on EMD-induced inhibition of allodynia during the 60-min observation period. *** p < 0.001 and **** p < 0.0001, compared with vehicle group; # p < 0.05, ### p < 0.001, and #### p < 0.0001 compared with 10 μg EMD. n = 8–11 rats/group.

    Journal: Frontiers in Neuroscience

    Article Title: The 5-HT 6 Receptors in the Ventrolateral Orbital Cortex Attenuate Allodynia in a Rodent Model of Neuropathic Pain

    doi: 10.3389/fnins.2020.00884

    Figure Lengend Snippet: The blocking effects of the non-selective glutamate receptor antagonist KA on EMD-induced anti-allodynia in the VLO. (A) The colocalization of 5-HT 6 receptors and EAAC1 in the VLO. Scale bar, 50 μm; n = 4 rats/group. (B) Time course curves showing the antagonizing effect of KA on EMD-induced inhibition of allodynia. (C) Scatter plots showing the antagonizing effect of KA on EMD-induced inhibition of allodynia during the 60-min observation period. *** p < 0.001 and **** p < 0.0001, compared with vehicle group; # p < 0.05, ### p < 0.001, and #### p < 0.0001 compared with 10 μg EMD. n = 8–11 rats/group.

    Article Snippet: After washing in PBS, sections were incubated with primary antibody anti-rabbit 5-HT 6 receptor (Bioss, bs-12058R, 1:1,000, Beijing, China) and anti-goat neuronal glutamate transporter (EMD Millipore, AB1520, 1:8,000, Temecula, CA, United States) for 48 h at 4°C.

    Techniques: Blocking Assay, Inhibition

    A schematic representation of the mechanisms underlying 5-HT 6 receptors’ regulation of SNI-induced mechanical allodynia. SNI-induced allodynia downregulates 5-HT 6 receptors specifically in the contralateral VLO. The downregulation of 5-HT 6 receptors, some of which are postsynaptically present in the glutamatergic neurons in the VLO, might subsequently decrease glutamate release via an AC/PKA cascade, thus resulting in allodynia. Therefore, selective 5-HT 6 receptor agonists may ameliorate some of these mal-adaptations by activation of 5-HT 6 receptors. GluR, glutamate receptors; 5-HT6R, 5-HT 6 receptors.

    Journal: Frontiers in Neuroscience

    Article Title: The 5-HT 6 Receptors in the Ventrolateral Orbital Cortex Attenuate Allodynia in a Rodent Model of Neuropathic Pain

    doi: 10.3389/fnins.2020.00884

    Figure Lengend Snippet: A schematic representation of the mechanisms underlying 5-HT 6 receptors’ regulation of SNI-induced mechanical allodynia. SNI-induced allodynia downregulates 5-HT 6 receptors specifically in the contralateral VLO. The downregulation of 5-HT 6 receptors, some of which are postsynaptically present in the glutamatergic neurons in the VLO, might subsequently decrease glutamate release via an AC/PKA cascade, thus resulting in allodynia. Therefore, selective 5-HT 6 receptor agonists may ameliorate some of these mal-adaptations by activation of 5-HT 6 receptors. GluR, glutamate receptors; 5-HT6R, 5-HT 6 receptors.

    Article Snippet: After washing in PBS, sections were incubated with primary antibody anti-rabbit 5-HT 6 receptor (Bioss, bs-12058R, 1:1,000, Beijing, China) and anti-goat neuronal glutamate transporter (EMD Millipore, AB1520, 1:8,000, Temecula, CA, United States) for 48 h at 4°C.

    Techniques: Activation Assay